Assessing the quality of stored red blood cells using handheld Spatially Offset Raman spectroscopy with multisource correlation analysis

Martha Z. Vardaki,H. Georg Schulze,Katherine Serrano,Michael W. Blades,Dana V. Devine,Robin F. B. Turner

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2022）

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摘要

•Storage-related changes were identified in Red Cell Concentrate using SORS.•MuSCA was employed to assess Raman data against parallel bioanalytical measurements.•Spectral markers strongly correlated with respective bioassays in RCC were revealed.•Our approach enabled direct quality monitoring of RCC within sealed transfusion bags.

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关键词

2D-COS,Raman spectroscopy,Multisource correlation analysis,Red blood cell concentrate,Inventory management,Transfusion efficacy,Storage lesion,Spatially Offset Raman spectroscopy

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