Red blood cell-hitchhiking mediated pulmonary delivery of ivermectin: Effects of nanoparticle properties

Jinpeng Zheng,Caihong Lu,Yaning Ding,Jinbang Zhang,Fangyun Tan,Jingzhou Liu,Guobao Yang,Yuli Wang,Zhiping Li,Meiyan Yang,Yang Yang,Wei Gong,Chunsheng Gao

International Journal of Pharmaceutics（2022）

引用 13|浏览12

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摘要

•Ivermectin-loaded nanoparticles were delivered to lungs through adsorption on RBCs.•RBC-hitchhiking strategy improved ivermectin pharmacokinetics and bioavailability.•Nanoparticle properties affected the characteristics of RBC-nanoparticles in vivo.

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关键词

Ivermectin,PLGA nanoparticle,chitosan,RBC-hitchhiking,acute lung injury

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