Microwave-enhanced synthesis of 26-amino-22-oxocholestanes and their cytotoxic activity

Juan P Aguilar-Barrientos,Rosa E Moo-Puc,Jairo R Villanueva-Toledo,Fernando Murillo,David Cáceres-Castillo,Gumersindo Mirón-López,María G De Los Santos,Jesús Sandoval-Ramírez,Reyna Zeferino-Díaz,María A Fernández-Herrera

Steroids（2022）

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摘要

•26-amino-22-oxocholestanes were synthesized from diosgenin.•MW heating provided the best yields and reaction times.•4-aminourazole yielded the 26-iminourazole-22-oxocholestane.•Two 26-aminosteroids showed cytotoxic activity on SiHa and MCF-7 cancer cells.

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关键词

22-oxocholestanes,Aminosteroids,Cytotoxic activity,Microwave-assisted reactions

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