Advances in CD247

CD247, which is also known as CD3 zeta, CD3H, CD3Q, CD3Z, IMD25, T3Z and TCRZ, encodes CD3 zeta protein, which is expressed primarily in natural killer (NK) and T cells. Since the discovery of the zeta peptide in 1986, it has been continuously investigated. In this paper, we review the composition, molecular mechanisms and regulatory factors of CD247 expression in T cells; and review the autoimmune diseases, tumours and inflammatory diseases associated with CD247, providing a detailed and comprehensive reference for further research on the mechanism of CD247 and related diseases.