Drug resistance biomarker ABCC4 of selinexor and immune feature in multiple myeloma

Fang Hu,Xiao-Qin Chen, Xue-Ping Li, Yu-Xiu Lu,Si-Liang Chen,Da-Wei Wang, Yang Liang,Yu-Jun Dai

International Immunopharmacology（2022）

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摘要

•The cytogenetic background of Selinexor sensitive MM patients was not limited to specific cytogenetic subtypes.•ABCC4 was identified as the biomarker to predict the therapeutic response and prognosis of Selinexor.•ABCC4 expression had a significantly positive correlation with NK infiltration and TIM-3 expression.

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关键词

RRMM,Selinexor,XPO1,ABCC4,Immune infiltration

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