m(6)A RNA modification in transcription regulation

RNA modifications are prevalent among all the classes of RNA, regulate diverse biological processes, and have emerged as a key regulatory mechanism in post-transcriptional control of gene expression. They are subjected to precise spatial and temporal control and shown to be critical for the maintenance of normal development and physiology. For example, m(6)A modification of mRNA affects stability, recruitment of RNA binding protein (RBP), translation, and splicing. The deposition of m(6)A on the RNA happens co-transcriptionally, allowing the tight coupling between the transcription and RNA modification machinery. The m(6)A modification is affected by transcriptional dynamics, but recent insights also suggest that m(6)A machinery impacts transcription and chromatin signature.