TRPM2 Plays a Minor Role in AKI and Kidney Fibrosis.

Yu Kurata,Tetsuhiro Tanaka,Hana Cernecka,Frank Eitner,Masaomi Nangaku

Kidney360（2022）

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摘要

TRPM2 is a Ca2-permeable cationic channel and serves as an oxidative stress sensor.TRPM2 deletion was harmful in renal ischemia-reperfusion injury, whereas TRPM2 deletion mitigated kidney fibrosis.Our findings suggest the role of TRPM2 in kidney diseases is context dependent.

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TRPM2,acute kidney injury,acute kidney injury and ICU nephrology,basic science,chronic kidney disease,fibrosis,ischemia-reperfusion injury

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