A nanoconfined loading strategy for highly efficient siRNA delivery and cancer therapy

Wangcheng Zhang,Yuxi Zhang,Yingli Luo,Senbiao Chen,Qiaoyi Huang,Zhiting Cao,Ming Liang,Xianzhu Yang

Nano Today（2022）

引用 7|浏览9

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摘要

•The nanoconfined loading strategy significantly enhanced the electrostatic interaction of cationic material and siRNA.•This nanoconfined strategy reduced by 70% amount of cationic material usage compared to conventional absorption strategy.•The prepared NCAPAMAM/siRNA improved tumor cell uptake of siRNA by releasing PAMAM/siRNA at acidic tumor microenvironment.•NCAPAMAM/siRNA carrying siPD-L1 efficiently suppressed PD-L1 expression for cancer immunotherapy.

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关键词

Nanoconfined assembly,siRNA delivery,Tumor acidity sensitive nanocarrier,PD-L1 knockdown,Cancer immunotherapy

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