Recent advancements of organotin(IV) complexes derived from hydrazone and thiosemicarbazone ligands as potential anticancer agents

Inorganic Chemistry Communications（2022）

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摘要

•This review emphasizes anticancer study of organotin(IV) complexes.•The rate of cancer related mortality is at alarming level globally.•The ligand scaffolds studied are hydrazones, thiosemicarbazones and carboxylates.•The n-butyl and phenyl derivatives of organotin(IV) complexes are most active.

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IC50,LC50,GI50,Bu,Ph,Me,5-FU,Et,Oct,Bz,MTT assay,SRB assay,NCI-H460, H-157, Hop-62, A-549,MCF-7, MDA-MB-231,HepG2, QSG-7701, HL-7702,HeLa, KB,HCT-8, HCT-116, HCT-15,HL-60, P-388, K-562,HT-29,Caco-2,SMMC-7721,HUVEC,HN-5,WRL-68,Skov-3, Caov-3,PC-3,U373MG,IMR-90,EAhy-926, HUVEC,T-24,L-929,L-6,CisR,BSA,ADME,BHK-21

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