Prostaglandins and calprotectin are genetically and functionally linked to the Inflammatory Bowel Diseases.

Mohamad Karaky,Gabrielle Boucher,Saraï Mola,Sylvain Foisy,Claudine Beauchamp,Marie-Eve Rivard, Melanie Burnette,Hugues Gosselin,Alain Bitton,Guy Charron,Philippe Goyette,John D Rioux

PLoS genetics（2022）

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摘要

Our results support a causal role for the PTGIR, PTGER4, ZBTB40, SLC39A11 and NFKB1 genes in IBD, with all five genes regulating the expression of CP in myeloid cells, as well as potential roles for the prostacyclin/prostaglandin biogenesis and signaling pathways in IBD susceptibility and pathogenesis.

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prostaglandins,calprotectin

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