Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma

Maria Davern, Noel E. Donlon,Fiona O’ Connell,Andrew D. Sheppard, Conall Hayes,Ross King, Hugo Temperley,Christine Butler, Anshul Bhardwaj,Jenny Moore,Dara Bracken-Clarke, Claire Donohoe,Narayanasamy Ravi, John V. Reynolds,Stephen G. Maher, Melissa J. Conroy,Joanne Lysaght

Translational Oncology（2022）

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摘要

•Immune checkpoints correlate with higher grade tumours and poor treatment response.•First-line chemotherapies stimulate anti-tumour T cell immunity.•Dual nivolumab-ipilimumab enhances lymphocyte-mediated killing of tumour cells.•Lymphocyte-mediated killing of tumour cells is enhanced by FLOT chemotherapy.

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PD-1,A2aR,CTLA-4,FLOT regimen,CROSS regimen

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