Signaling sphingolipids are biomarkers for atopic dermatitis prone to disseminated viral infections

Evgeny Berdyshev,Elena Goleva,Irina Bronova,Anna Sofia Bronoff,Joanne E Streib,Kathryn A Vang,Brittany N Richers,Patricia Taylor,Lisa Beck,Miguel Villarreal,Keli Johnson,Gloria David,Mark K Slifka,Jon Hanifin,Donald Y M Leung

Journal of Allergy and Clinical Immunology（2022）

引用 6|浏览22

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摘要

Our data point to long-term abnormalities in the S1P signaling system as a biomarker for previous disseminated viral diseases and a potential treatment target in recurring infections.

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关键词

Eczema vaccinatum,eczema herpeticum,stratum corneum,plasma,human primary keratinocytes,sphingosine-1-phosphate,ceramide,S1P/ceramide ratio,S1P lyase

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