Mitigation of liver fibrosis via hepatic stellate cells mitochondrial apoptosis induced by metformin

Ying Su,Shan Lu,Chenjian Hou,Kehan Ren,Meili Wang,Xiaoli Liu,Shanyu Zhao,Xiuping Liu

International Immunopharmacology（2022）

引用 2|浏览6

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摘要

•Metformin activates caspase-9-mediated mitochondrial apoptosis pathway.•Metformin promoted cytochrome c release.•Metformin broke the balance between Bcl-2 family in HSCs.•Metformin relieves liver lesions of NASH-associated fibrosis mice models.

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关键词

Liver fibrosis,Hepatic stellate cells (HSCs),Metformin,Mitochondrial apoptosis,Nonalcoholic steatohepatitis (NASH)

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