Isotope labelled in suit derivatization-extraction integrated system for amine/phenol submetabolome analysis based on nanoconfinement effect: Application to lung cancer

•An in suit derivatization-extraction integrated system was established.•Combined with isotope labelling derivatization, the accuracy was enhanced.•Amine/phenol submetabolome of human plasma was profiled.•Potential diagnosis biomarkers in lung cancer plasma were screened out.