Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats
Biochemical and Biophysical Research Communications（2022）
摘要
•Presympathetic neurons modulates sympathetic outflow.•Presympathetic neurons contributes to the pathogenesis of neurogenic hypertension.•EET signaling is important to sympathetic nerve activity regulation.•AAV-mediated downregulation of EPHX2 reduced neuronal excitability in the PVN.•Astrocytic ATP/SR/D-serine contributes to the effect of 14,15-EET on neurons.
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关键词
Neurogenic hypertension,Spontaneously hypertensive rats,Soluble epoxide hydrolase,Epoxyeicosatrienoic acids,Paraventricular nucleus neurons,Hypothalamic astrocytes
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