Significance of plasma fibrinogen and malondialdehyde in the post-inflammatory period in patients with cystic fibrosis

OBJECTIVES: Evaluation of selected infl ammatory parameters and serum malondialdehyde (MDA) signifi cance in the post-infl ammatory period in adult patients with cystic fi brosis. BACKGROUND: Laboratory biomarkers can be integrated into clinical practice as part of monitoring the effectiveness of treatment. METHODS: After recovery from an acute exacerbation of lung infection, selected infl ammatory parameters (fi brinogen, IL-1, IL-6, SAA, hs-CRP) and serum MDA were examined in 30 adult patients with cystic fi brosis. Their correlation with FEV1, frequency and duration of subsequent hospitalizations and 6-year prognosis in terms of mortality or need for lung transplantation was evaluated. RESULTS: FEV1 negatively correlated with fi brinogen, but positively with MDA. No signifi cant correlation with hs-CRP, IL-1, IL-6 and SAA was recorded. Plasma fi brinogen predicted the frequency and duration of subsequent hospitalizations. The 6-year prognosis was negatively associated with plasma fi brinogen whereas its association with MDA was positive. However, the prognosis of patients in the multivariate analysis was CONCLUSION: Plasma fi brinogen examined in the post-infl ammatory period is a marker of lung damage in patients with cystic fi brosis and can be used to predict the prognosis. The positive correlation of serum MDA with FEV1 in the post-infl ammatory period may be important to the interpretation of treatment interventions (Tab. 3, Fig. 2, Ref. 17). Text in PDF www.elis.sk malondialdehyde, fibrinogen, prognosis.