PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice

Guen Tae Kim,Eun Young Kim,Su-Hyun Shin,Hyowon Lee,Se Hee Lee,Kaapjoo Park,Ki-Young Sohn,Sun Young Yoon,Jae Wha Kim

Translational Oncology（2022）

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摘要

•PLAG effectively relieves cachexia symptoms caused by chemotherapy.•PLAG restores leg muscles atrophy by cisplatin to normal levels.•PLAG returns cachexia-related elements modulated by cisplatin to normal levels.•PLAG did not downregulate the anti-tumor effect of cisplatin.

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关键词

PLAG,Cisplatin,Cachexia,Muscle atrophy,Lung carcinoma

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