Anti-Nociceptive and Anti-Aversive Drugs Differentially Modulate Distinct Inputs to the Rat Lateral Parabrachial Nucleus

Hannah Luise Teuchmann,Roni Hogri,Bernhard Heinke,Jürgen Sandkühler

The Journal of Pain（2022）

引用 3|浏览1

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摘要

•Spinal projections to the lateral parabrachial nucleus (LPBN) are glutamatergic.•Periaqueductal grey matter (PAG)-LPBN projections are glutamatergic and GABAergic.•Opioids reduce synaptic transmission at spinal and both PAG-LPBN synapses.•Cannabinoids reduce excitatory and inhibitory PAG-LPBN synaptic transmission.•Benzodiazepines enhance inhibitory transmission at PAG-LPBN synapses.

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Lateral parabrachial nucleus,pain aversion,opioids,benzodiazepines,cannabinoids

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