Foslevodopa/foscarbidopa subcutaneous infusion maintains equivalent levodopa exposure to levodopa-carbidopa intestinal gel delivered to the jejunum

Matthew Rosebraugh,Sven Stodtmann,Wei Liu,Maurizio F Facheris

Parkinsonism & Related Disorders（2022）

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摘要

•Foslevodopa/foscarbidopa LD exposures are comparable to LCIG in healthy volunteers.•LD degree of fluctuation was low for foslevodopa/foscarbidopa infusion and LCIG.•Foslevodopa/foscarbidopa maintains LD exposure within a narrow therapeutic window.

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关键词

Levodopa,Carbidopa,Parkinson's disease,Pharmacokinetics

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