Artesunate restrains the malignant progression of human cutaneous squamous cell carcinoma cells via the suppression of the PI3K/AKT pathway

Tissue and Cell（2022）

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摘要

•ART notably alleviated CSCC cell malignant phenotypes.•ART attenuated cell cycle-, apoptosis-, and PI3K/AKT pathway-related markers in CSCC cells.•The suppression of ART on CSCC cell malignant phenotypes were reversed by IGF-I.

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关键词

Cutaneous squamous cell carcinoma,Artesunate,Apoptosis,Cell cycle,PI3K/AKT pathway

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