Targeted protein degraders: a call for collective action to advance safety assessment
NATURE REVIEWS DRUG DISCOVERY(2022)
摘要
Targeted protein degraders (TPDs) are emerging classes of therapeutics that have the potential to address difficult drug targets in new ways. In 2021, experts convened to discuss challenges in TPD safety evaluation, and supported supplementing individual efforts to address these challenges with collective development of novel decision frameworks, tools and a shared evidence base.
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