Gene-Environment Interactions between Environmental Noise and ApoE4 Causes AD-Like Neuropathology in the Hippocampus in Male Rats

Wen Long LI,Yuan Yuan LI,Yu Xin LI, Yu FU, Xian Zhi HE, Fei Yan TAO, Ruo Lan YOU,Ruo Yu ZHANG, Ming Qing ZHONG, Hui Min CHI,Qing Feng ZHAI

Biomedical and Environmental Sciences（2022）

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摘要

Experimental evidence has demonstrated that environmental hazards can induce neurodegeneration such as Alzheimer’s disease（AD） [1] . The pathogenesis of AD, characterized by a gradual cognitive decline, overproduction of β-amyloid（Aβ）, and hyperphosphorylated tau in specific brain areas,

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