Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents

Jonathan M Hazlehurst,Teegan Reina Lim,Catriona Charlton,Jack J Miller,Laura L Gathercole,Thomas Cornfield,Nikolaos Nikolaou,Shelley E Harris,Ahmad Moolla,Nantia Othonos,Lisa C Heather,Thomas Marjot,Damian J Tyler,Carolyn Carr,Leanne Hodson,Jane McKeating,Jeremy W Tomlinson

Metabolism Open（2022）

引用 4|浏览24

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摘要

•Acute intermittent hypoxia increases hepatic de novo lipogenesis in humans in vivo.•Prolonged intermittent hypoxia in rodent models increases hepatic de novo lipogenesis.•The effect of hypoxia on de novo lipogenesis in cell lines is reliant on hypoxia-inducible factors.

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关键词

NAFLD,Hypoxia,HIF,Lipid metabolism

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