Early Alzheimer's disease-like reductions in gray matter and cognitive function with aging in nonhuman primates.

Brett M Frye,Suzanne Craft,Thomas C Register,Jeongchul Kim,Christopher T Whitlow,Richard A Barcus,Samuel N Lockhart,Kiran Kumar Solingapuram Sai,Carol A Shively

Alzheimer's & dementia (New York, N. Y.)（2022）

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摘要

Cortical gray matter diminishes with age in vervets in regions relevant to AD, which may increase risk of cognitive impairment. This study lays the groundwork for future investigations to test therapeutics to delay or slow pathological decline.

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关键词

Alzheimer's disease,magnetic resonance imaging,non‐human primate,vervet,working memory

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