The cerebral haemodynamic response to somatosensory stimulation in preterm newborn lambs is reduced following intrauterine inflammation and dopamine infusion

Ishmael M. Inocencio,Nhi T. Tran,Manon Wiersma, Katja Stoecker,Shinji Nakamura,Timothy J. Moss,David W. Walker,Flora Y. Wong

Experimental Neurology（2022）

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摘要

•First to investigate how chorioamnionitis affects the cerebral functional response.•Chorioamnionitis leads to negative cerebral functional response in preterm brain.•Dopamine may further reduce cerebral oxygen delivery relative to consumption.

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关键词

Chorioamnionitis,Intrauterine inflammation,Dopamine,Preterm brain,Cerebral functional haemodynamic response,Neurovascular coupling

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