Characterizing kinase intergenic-breakpoint rearrangements in a large-scale lung cancer population and real-world clinical outcomes

•Kinase IGRs were recurrent in patients with lung cancer, with clinically-druggable kinase genes being the most frequent.•The molecular features of IGRs were studied, e.g. inter-/intra-chromosome, kinase domain integrity, and promoter involvement.•A subset of DNA-level IGR events was validated by RNA-seq and/or IHC assays which confirmed the chimeric fusion products.•The potential oncogenic function of kinase IGRs was illustrated and may facilitate the administration of targeted therapies.