Associations of the MUC5B promoter variant with timing of interstitial lung disease and rheumatoid arthritis onset.

Gregory McDermott,Ritu Gill,Staci Gagne,Suzanne Byrne,Weixing Huang,Jing Cui,Lauren Prisco,Alessandra Zaccardelli,Lily Martin,Vanessa L Kronzer,Matthew Moll,Michael H Cho,Nancy Shadick,Paul F Dellaripa,Tracy Doyle,Jeffrey A Sparks

Rheumatology (Oxford, England)（2022）

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摘要

The common MUC5B promoter variant was associated with RA-ILD onset earlier in the RA disease course and older age of RA onset. These findings suggest that the MUC5B promoter variant may impact RA-ILD risk early in the RA disease course, particularly in patients with older-onset RA.

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CT scanning,RA,epidemiology,genetics,respiratory

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