Swelling-induced upregulation of miR-141-3p inhibits hepatocyte proliferation

Nils Bardeck,Martha Paluschinski,Mirco Castoldi,Claus Kordes,Boris Görg,Jan Stindt,Tom Luedde,Stephan vom Dahl,Dieter Häussinger,David Schöler

JHEP Reports（2022）

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摘要

•Gene expression changes in hypoosmotic perfused rat liver.•Hypoosmolarity upregulates miR-141-3p in rat perfused liver and primary hepatocytes.•Src-/Erk-/p38-MAPK-inhibition prevents miR-141-3p upregulation by hypoosmolarity.•PHx and hepatocyte stretch transiently upregulate miR-141-3p, which downregulates Cdk8 mRNA.•Overexpression of miR-141-3p inhibits Huh7 cell proliferation.

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关键词

Hypoosmolarity,Osmosis,Liver perfusion,Hepatocytes,microRNA,miR-141-3p,Colchicine,PHx,Liver regeneration

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