Effect of pentoxifylline and α-tocopherol on medication-related osteonecrosis of the jaw in rats: Before and after dental extraction

Gabrielle Delfrate, Tayline Mroczek,Leomar Emanuel Almeida Mecca,Jéssica Daniela Andreis,Daniel Fernandes,Leandro Cavalcante Lipinski,Marcela Claudino,Gilson Cesar Nobre Franco

Archives of Oral Biology（2022）

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摘要

•Treatment with pentoxifylline and tocopherol reduced the incidence of MRONJ.•The treatment increased blood flow and number of osteocytes.•Prevention with pentoxifylline and tocopherol did not reduce the incidence of MRONJ.•The prevention did not increase blood flow and number of osteocytes.•Zoledronic acid impaired prevention with pentoxifylline and tocopherol.

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关键词

Bisphosphonates,Oral surgery,Osteonecrosis,Phosphodiesterase inhibitors,Vitamin E

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