Mortality associated with third-generation cephalosporin resistance in Enterobacteriaceae bloodstream infections at one South African hospital

Angela Dramowski,Alexander M Aiken,Andrea M Rehman,Yolandi Snyman,Sandra Reuter,Hajo Grundmann,J Anthony G Scott,Marlieke E A de Kraker,Andrew Whitelaw

Journal of Global Antimicrobial Resistance（2022）

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摘要

•Global AMR impact estimates require new primary data from African countries.•We studied impacts of third-generation cephalosporin resistance (3GC-R) in South Africa.•Uninfected patient matching and clinical outcome measurement was feasible.•Sequencing demonstrated correlation of phenotypic 3GC-R with ESBL gene presence.•Estimates of impact size had broad confidence intervals in this single-site study.

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关键词

Mortality,Bloodstream infection,Enterobacteriaceae,Extended-spectrum β-lactamase,Antibiotic resistance,South Africa

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