Improved Synthesis of First Cell-Permeable Allosteric PTPRZ Inhibitor NAZ2329
Russian Journal of General Chemistry(2021)
摘要
NAZ2329 is the first cell-permeable small molecular allosteric inhibitor of protein tyrosine phosphatase receptor–type Z (PTPRZ), which was considered as a new potential molecular target for drug development in glioblastoma. A facile and high-efficient synthesis of NAZ2329 was developed by a straight-forward strategy starting from key ethoxy benzyl bromide intermediate obtained from commercially available 4-(trifluoromethyl)phenol.
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关键词
NAZ2329,synthesis,PTPRZ
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