Comparative Transcriptome and Lipidome Analyses Suggest a Lipid Droplet-Specific Response to Heat Exposure of Brown Adipose Tissue in Normal and Obese Mice

Qiankun Wang,Yi Jin,Yue Liu, Yue Xu,Jian Wu,Zhuqing Ren

SSRN Electronic Journal（2022）

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摘要

Heat treatment (40 °C, 4 h) produced different effects on the lipids of iBAT in normal and obese mice. LDLR, low-density lipoprotein cholesterol receptor; HSPs, heat shock proteins; CHO, cholesterol; CE, cholesteryl ester; ER, endoplasmic reticulum; Mito, mitochondria; ROS, reactive oxygen species; red arrows suggesting up-regulation or activation; blue arrows suggesting down-regulation or inhibition.Unlabelled Image

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关键词

Heat exposure,iBAT damage,Obesity,Lipid droplets,Hyperthermia adaptation

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