Pharmacophore optimization of imidazole chalcones to modulate microtubule dynamics

Endri Karaj,Samkeliso Dlamini,Radhika Koranne,Shaimaa H. Sindi,Lalith Perera,William R. Taylor,L.M. Viranga Tillekeratne

Bioorganic Chemistry（2022）

引用 3|浏览8

暂无评分

摘要

•Structure-activity relationship of imidazole chalcone mimics.•Cytotoxic with IC50 values in the upper nanomolar to low micromolar range.•Compounds caused mitotic arrest of HeLa cells.•Compounds induced dramatic disassembly of the mitotic spindle.•Docking studies show binding to colchicine binding site.

查看译文

关键词

Antimitotic agents,SAR,Imidazole chalcones,Mitotic spindle,Microtubule dynamics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要