Schistosomicidal evaluation of synthesized bromo and nitro chalcone derivatives

Camila Marcovicz,Guilherme dos Anjos Camargo,Bianca Scharr,Larissa Sens, Mariana Negrelli Levandowski,Thiago de Castro Rozada,Patrícia Castellen,Juliana Inaba,Rosimeire Nunes de Oliveira,Júlio César Miné,Sheila de Andrade Penteado Corrêa,Silmara Marques Allegretti,Barbara Celânia Fiorin

Journal of Molecular Structure（2022）

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摘要

•Chalcones evaluated presented promising schistosomicidal effects.•Chalcones evaluated have a conformational preference for s-cis geometry.•The ortho-substituents chalcones presented possible relation between s-trans geometries with schistosomicidal effects.•NMR spectroscopy was used for characterization.

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关键词

Chalcone,Conformational analysis,Schistosomicidal activity

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