Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats.
CNS & neurological disorders drug targets(2022)
摘要
Berberine may mitigate vascular cognitive dysfunction by promoting neuronal plasticity, inhibiting microglial activation, promoting transformation from an M1 to an M2 phenotype, and increasing levels of IL-4 and IL-10 expression.
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关键词
Chronic cerebral hypoperfusion,Interleukin-10 (IL-10),Interleukin-4 (IL-4),berberine,microglia,neurons,vascular cognitive impairment
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