Combination of fabric phase sorptive extraction with UHPLC-ESI-MS/MS for the determination of adamantine analogues in human urine

Georgia Sidiropoulou,Abuzar Kabir,Kenneth G. Furton,Fotini S. Kika,Konstantinos Fytianos,Paraskevas D. Tzanavaras,Constantinos K. Zacharis

Microchemical Journal（2022）

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摘要

•A FPSE was developed for the isolation of adamantine analogues.•Fast and direct extraction of the biological matrices in less than 20 min.•Sensitive determination of the analytes in biological samples using UHPLC-MS/MS.

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关键词

Fabric phase sorptive extraction,Amantadine,Memantine,Rimantadine,Human urine,LC-MS/MS

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