Polygenic score development in the era of large-scale biobanks.

In this issue of Cell Genomics, Xu et al. report a comprehensive analysis of the genetics of 26 blood cell traits, leveraging data from two large biobanks to construct and make available machine-learning optimized polygenic scores (PGSs). In addition to delivering insights into the biology and clinical associations of these traits, the authors evaluate and provide recommendations on methods for PGS construction.