The PET tracer [
11
C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease
Wenping Li,Yuchuan Wang,Talakad G. Lohith,Zhizhen Zeng,Ling Tong,Robert Mazzola, Kerry Riffel,Patricia Miller,Mona Purcell,Marie Holahan,Hyking Haley,Liza Gantert,David Hesk,Sumei Ren,John Morrow,Jason Uslaner,Arie Struyk,Jenny Miu-Chun Wai,Michael T. Rudd,David M. Tellers,Thomas McAvoy,Guy Bormans,Michel Koole,Koen Van Laere,Kim Serdons,Jan de Hoon,Ruben Declercq,Inge De Lepeleire,Maria B. Pascual,Paolo Zanotti-Fregonara,Meixiang Yu,Victoria Arbones,Joseph C. Masdeu,Amy Cheng,Azher Hussain,Tjerk Bueters,Matt S. Anderson,Eric D. Hostetler,Anthony S. Basile Science Translational Medicine（2022）
摘要
[ 11 C]MK-6884 is an M4R-specific PET tracer for quantifying target engagement in brain and providing insights into AD neuropathology.
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