Role of Cannabidiol and Tetrahydrocannabivarin on Paclitaxel-induced neuropathic pain in rodents

•THCV, when combined with CBD, provides excellent neuroprotection against paclitaxel-induced peripheral neuropathy in mice.•THCV and CBD improve mitochondrial health and neuron function by modulating CB1 and 5HT1A receptors, respectively.•After blocking CB1 and 5HT1A receptors in PTX-injured DRG primary cultures, THCV and CBD have no effect on neurite outgrowths, mitochondrial membrane potentials, or mitochondrial superoxide production.