Association of PD-L1 Expression on Tumor and Immune Cells with Survival in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Assay Validation.

Sophie Wildsmith,Jiabu Ye,April Franks,Giovanni Melillo,Jon Armstrong,Jessica Whiteley, Karina Schnittker,Fangru Lian, Bryan Roland, Constantine Sabalos, Payam Ahmadi,Jerome Fayette,Caroline Even,Ricard Mesía,Lillian L. Siu,Dan P. Zandberg,Jill Walker

Cancer research communications（2022）

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摘要

A novel algorithm for PD-L1 expression using the cut-off point TC ≥ 50%/IC ≥ 25% is robust for identifying patients with HNSCC most likely to benefit from durvalumab treatment and can be reproducibly scored by trained pathologists.

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