Preimplantation Genetic Testing for Aneuploidy: Has the Controversy Settled? A Review

Purpose of Review This review is aimed at providing an overview of the development of, and advances in preimplantation genetic testing for aneuploidy (PGT-A) in the last decade. It will summarize advances in the field to date, ongoing controversies, and explore ideas for future directions. Recent Findings Recent findings in the field of PGT-A include the publication of the STAR trial in 2019. This large RCT failed to find a benefit for PGT-A in women aged 25–40. As a result of increasing use of PGT-A with comprehensive genomic sequencing, the number of mosaic embryos identified has increased, with an ongoing debate as to the use of these embryos. Further research in this field includes the development of non-invasive pre-implantation testing, which may overcome some of the challenges noted in the field to date. Summary This review primarily focuses on the controversies in the field surrounding PGT-A, with suggestions for further research.