Impaired immunomodulatory effects of seminal plasma may play a role in unexplained recurrent pregnancy loss: Results of an in vitro study

N A du Fossé, E E L O Lashley, J D H Anholts,E van Beelen,S le Cessie,J M M van Lith,M Eikmans,M L P van der Hoorn

Journal of Reproductive Immunology（2022）

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摘要

•Seminal plasma (SP) induced changes in gene expression of female immune cells.•Changes in gene expression compatible with induction of more regulatory phenotype.•Immunomodulatory effects of SP impaired in unexplained recurrent pregnancy loss.•Immunomodulatory effects of SP correlated with immunological factors present in SP.

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关键词

Seminal plasma,Recurrent pregnancy loss,MRNA expression,Immunology,Reproductive immunology

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