Lack of DOCK8 impairs the primary biologic functions of human NK cells and abrogates CCR7 surface expression in a WASP-independent manner

Ornella Patrizi,Manuela Baronio,Luisa Gazzurelli,Stefano Rossi,Sara Rezzola,Emanuela Marcenaro,Alessandro Plebani,Raffaele Badolato,Silvia Parolini,Vassilios Lougaris,Giovanna Tabellini

Clinical Immunology（2022）

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摘要

Dedicator of Cytokinesis 8 (DOCK8) deficiency is a rare form of autosomal recessive combined immunodeficiency. The effect of DOCK8 deficiency on Natural Killer cell biology has not been fully elucidated yet. Thus, we undertook a detailed phenotypic and functional evaluation of NK cells from seven patients with DOCK8 deficiency.

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关键词

Dedicator of cytokinesis 8,Natural killer cells,C-C motif chemokine receptor 7,Wiskott-Aldrich syndrome protein

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