Microencapsulated islet transplantation alleviates podocyte injury in diabetic nephropathy via inhibiting Notch-1 signaling

Jixiang Yuan,Feihong Lin,Lichen Chen,Hongjian Huang,Xiaojie Ni,Xiaodong Pan,Bicheng Chen,Yong Cai

Transplant Immunology（2022）

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摘要

•In vivo diabetic nephropathy mouse model was constructed using streptozotocin.•Microencapsulated islet transplantation improved the clinical condition of DN.•Notch-1 signaling pathways influence podocyte restoration.•Renal function and glomerular filtration barrier structure were assessed.

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关键词

Diabetic nephropathy,Podocytes,Microencapsulated islet transplantation,Notch pathway,Diabetes mellitus

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