Dickkopf-1 directs periosteal bone formation in two murine models of inflammatory arthritis.

A T Shaw,J Yan, S A Kuhstoss,J F Charles,E M Gravallese

Scandinavian journal of rheumatology（2022）

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摘要

DKK1 is a regulator of periosteal bone formation in inflammatory arthritis. Thus, regulation of DKK1 may be considered as a therapeutic approach in inflammatory diseases in which patients suffer from excessive periosteal bone formation, such as spondyloarthritis.

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