Mechanisms of Lian-Gui-Ning-Xin-Tang in the treatment of arrhythmia: Integrated pharmacology and in vivo pharmacological assessment

•Maintaining Ca2+ balance is an important mechanism of LGNXT against arrhythmia.•β-AR/cAMP/PKA/Ca2+ system signaling hub can constitute a promising molecular target for the development of novel antiarrhythmic therapeutic interventions.•Integrated pharmacology is an effective method in the study of TCM.•TCM treatment of diseases is a multi-target comprehensive effect.•Our study provides a good model for TCM research.