Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress

Anfal Al-Mass,Pegah Poursharifi,Marie-Line Peyot,Roxane Lussier,Emily J Levens,Julian Guida,Yves Mugabo,Elite Possik,Rasheed Ahmad,Fahd Al-Mulla,Robert Sladek,S R Murthy Madiraju,Marc Prentki

Molecular Metabolism（2022）

引用 4|浏览21

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摘要

•G3PP operates a glycerol shunt in β-cells to remove excess glucose as glycerol.•Inducible β-cell specific G3PP-KO (BKO) mice show hyperinsulinemia.•BKO mice show enhanced body weight and glucose induced insulin secretion.•BKO isolated islets show elevated insulin secretion only at high glucose.•Chronic exposure of BKO isolated islets to high glucose enhances glucotoxicity.

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关键词

Glycerol-3-phosphate phosphatase,Glycerol shunt,Glucose-stimulated insulin secretion,Glucodetoxification,Pancreatic beta cell,Type 2 diabetes,Obesity

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