POSA305 A Systematic Comparison of the Meta-Analysis Software Landscape and Validation of Metaxact for Meta-Analysis of Sparse Outcomes

While meta-analysis has become a prominent cornerstone of scientific medicine in the domain of therapeutics, there is no consensus on which software has the state-of-the-art features to be used for health technology assessment submissions with high degree of methodological comprehensiveness, flexibility, and usability. Furthermore, no systematic evaluation of meta-analysis software has been conducted since 2007 and since then, the meta-analysis software landscape has changed dramatically. The Objectives: of this study were to systematically compare features, flexibility, and usability of MetaXact, RevMan 5.0, Comprehensive Meta-analysis Software, STATA, and R and to validate MetaXact outputs against other meta-analysis software platforms.