All-in-one hollow nanoformulations enabled imaging-guided Mn-amplified chemophototherapy against hepatocellular carcinoma

•A facile method is established to optimize delivery of multi-therapeutics.•An all-in-one nanoformulation is constructed to elicit enhanced chemo-/photodynamic therapy.•Co-delivered Mn amplifies chemo-/photodynamic outcomes via ROS conversion and redox-homeostasis disruption.