Microalgae-based bioactive hydrogel loaded with quorum sensing inhibitor promotes infected wound healing

•A quorum sensing inhibitor based on a bioactive hydrogel to interrupt the QS of bacteria, relieve hypoxia, and destroy biofilms.•Berberine loaded living microalgae Spirulina platensis to form a bioactive hydrogel (BBR@SP gel) .•BBR@SP gel generate synergistic quorum sensing inhibition against MRSA via combined chemo-photodynamic therapy.•BBR@SP can suppresses and destroys biofilm, down-regulate expression of virulence factors, and could accelerate a MRSA-infected diabetic wound healing .